The most accurate is the method of PCR diagnostics (polymerase chain reaction), which allows you to determine the causative agent of Whipple's disease, both in a biopsy specimen and in other biological media.

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To eliminate the symptoms of malabsorption, the patient is prescribed a special diet enriched with animal proteins with a limited fat content (up to 30 g per day). To eliminate the symptoms of Imdur and abdominal discomfort, patients are prescribed antispasmodics that slow down intestinal motility.

The effectiveness of the therapy used is evaluated by conducting a repeated histological examination of the biopsy. The main sign of the effectiveness of treatment is a decrease in the number of macrophages in the test sample or their complete absence. Symptoms of Whipple's disease may take longer to appear due to the extent of organ damage. The information is generalized and is provided for informational purposes only. Seek medical attention at the first sign of isosorbide. Self-medication is dangerous to health! Whipple's disease: symptoms, diagnosis and treatment.

Whipple's disease (synonymous with intestinal lipodystrophy) is considered a rare disease that affects the small intestine and some other internal organs. Therefore, many doctors forget about its existence. Meanwhile, this disease with timely competent treatment has a favorable outcome.

Modern researchers believe that Whipple's disease is caused by certain types of bacilli Tropheryma whippelii, which penetrate, accumulate and multiply in immune cells - macrophages. In healthy people, these cells engulf and destroy infectious agents, but in this case, the bacilli remain intact.

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Further, the altered macrophages accumulate in the small intestine mucosa (infiltrate it). This leads to a significant decrease in the absorption of nutrients broken down by digestive enzymes into the blood. Their transport is interrupted at the level of the small intestine, so droplets of fat form in the mucosa (lipodystrophy). They further aggravate changes in the absorption of vitamins, proteins, minerals, carbohydrates and fats. Then this process passes to the mesenteric (intra-abdominal) lymph nodes and reaches other organs (myocardium, joints, peritoneum, pericardium, pleura, brain, etc.) through the lymphatic pathways.

Intestinal lipodystrophy occurs predominantly in men. The average age of patients approaches 50, although Whipple's disease can also affect very young people.

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Later, after 1–2 years, intestinal (intestinal) symptoms manifest, and metabolic disorders develop due to absorption disorders of the food components necessary for the body. The patient begins to worry: diarrhea up to 10 times a day (foamy feces with a high content of light brown fats); sometimes tarry stools (vitamin K malabsorption contributes to reduced blood clotting and bleeding); bloating alivethat; umbilical cramping pains; progressive weight loss; increasing fatigue from any load; signs of a lack of vitamins and minerals (swelling and inflammation of isosorbide pills, peeling and pigmentation of the skin, seizures, neurological disorders, etc.); nausea; loss of appetite.

With the development of the last of these stages, the patient may have various problems. Their character is determined by the localization of the diseased organs.

Not every specialist remembers Whipple's disease. However, it can be suspected already on the basis of a consistently unfolding clinical picture. To fully confirm a rare diagnosis, diagnostic procedures will be required: After verifying the diagnosis, doctors can begin complex treatment. The patient must understand that it will take a long time (at least a year) and will require some patience. Short-term chaotic swallowing of different pills will only aggravate the difficult situation and cause relapses (resumption) of Whipple's disease.

Therapy for intestinal lipodystrophy includes: a high-protein diet with fat restriction (lean meat, chicken breasts, river fish, egg white, dairy products, soy, buckwheat and oatmeal, seafood are recommended, some malnourished patients are even prescribed artificial nutrition with special mixtures sold in pharmacies or intravenous solutions); antibiotics (tetracyclines, penicillins, rifampicin, etc.) for a long course; antimicrobial agents (Cotrimoxazole, etc.); hormones (prednisolone and others are needed in serious cases); vitamins (D, B, A, etc.); preparations of imdur, iron, potassium, magnesium.

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With adequate treatment, the temperature returns to normal, and diarrhea decreases by the end of the first week. Joint pains regress within a month. But such a remarkable dynamics does not serve as a signal for the completion of treatment. Patients should be constantly under close medical supervision. Numerous repeated biopsy studies are needed to determine the true dynamics of the disease.

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For a long time, Whipple's disease was thought to be fatal. The use of intensive antibiotic therapy makes the prognosis more favorable. Antibiotics are used in the treatment of Whipple's disease. The most effective among them are tetracycline drugs. Dosage and timing of therapy are determined on the basis of histological studies in each case individually. In severe forms of the disease, patients often require additional symptomatic treatment.

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