Isosorbide is a heterocyclic compound that is derived from glucose, used as a diuretic
Further, the altered macrophages accumulate in the small intestine mucosa (infiltrate it). This leads to a significant decrease in the absorption of nutrients broken down by digestive enzymes into the blood. Their transport is interrupted at the level of the small intestine, so droplets of fat form in the mucosa (lipodystrophy). They further aggravate changes in the absorption of vitamins, proteins, minerals, carbohydrates and fats. Then this process passes to the mesenteric (intra-abdominal) lymph nodes and reaches other organs (myocardium, joints, peritoneum, pericardium, pleura, brain, etc.) through the lymphatic pathways.
Intestinal lipodystrophy occurs predominantly in men. The average age of patients approaches 50, although Whipple's disease can also affect very young people.